8 Biological Databases
GeneXplor aggregates and standardizes data from the world's most trusted genomic and biomedical consortia into a single, unified interface.
| Consortium / Database | Biological Focus | Key Insights Provided |
|---|---|---|
| Ensembl | Genomic Coordinates & Transcripts | Establishes the foundation of the gene model, defining exact chromosomal locations, canonical transcripts, biotypes (e.g., protein-coding vs lncRNA), and exon boundaries. |
| UniProt | Functional Proteomics | Reveals what the resulting protein actually *does*. Provides functional descriptions, domain maps (like Zinc fingers or Kinase domains), subcellular location, and sequence length. |
| ClinVar (NCBI) | Genomic Epidemiology & Phenotypes | The clinical backbone. Links specific DNA changes to observed human diseases and tracks the historical timeline of variant classifications (Pathogenic, VUS, Benign). |
| gnomAD | Population Genetics | Provides the allele frequency denominator. Essential for determining if a variant is genuinely rare, or just common in an under-sampled ancestral population (e.g., African/American). |
| PubMed (NCBI) | Biomedical Literature | Tracks the cadence of scientific discovery. Provides abstracts, publication dates, and citation trends to help researchers find the seminal papers documenting a gene's relevance. |
| AlphaFold DB | Structural Biology | Transforms 1D sequences into 3D conformational models. Crucial for visualizing whether a mutation is buried in the hydrophobic core or exposed on an interacting surface. |
| STRING | Protein Networks | Maps out the gene's functional "neighborhood". Provides evidence-scored webs of interacting proteins, helping identify unknown pathways and multi-protein complexes. |
| Reactome | Systems Biology | Embeds the gene into the broader machinery of the cell. Categorizes hierarchical biochemical pathways (like Signal Transduction or Apoptosis) that the gene participates in. |